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Cellosaurus ATN-1 (CVCL_1073)

[Text version]
Cell line name ATN-1
Synonyms ATN1
Accession CVCL_1073
Resource Identification Initiative To cite this cell line use: ATN-1 (RRID:CVCL_1073)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: ~24 hours (PubMed=3260813).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Leu (c.814G>C); ClinVar=VCV000574679; Zygosity=Homozygous (Cosmic-CLP=910687; DepMap=ACH-002058).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.05
East Asian, North78.58
East Asian, South17.98
South Asian1.43
European, North0
European, South1.95
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910687; RCB=RCB1440

Markers:
AmelogeninX,Y
CSF1PO9,11
D5S81810,13
D7S8208
D13S31711,12
D16S53911
TH019
TPOX9
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=3260813; DOI=10.1016/0165-4608(88)90171-9
Naoe T., Akao Y., Yamada K., Utsumi K.R., Koike K., Shamoto M., Koie K., Kurosawa Y., Kato K., Abe M., Shiku H.
Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells.
Cancer Genet. Cytogenet. 34:77-88(1988)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) RCB; RCB1440
Cell line databases/resources CLO; CLO_0050985
cancercelllines; CVCL_1073
Cell_Model_Passport; SIDM00233
Cosmic-CLP; 910687
DepMap; ACH-002058
LINCS_LDP; LCL-1025
Biological sample resources BioSample; SAMN03472143
Chemistry resources ChEMBL-Cells; CHEMBL3308183
ChEMBL-Targets; CHEMBL2366277
GDSC; 910687
PharmacoDB; ATN1_68_2019
PubChem_Cell_line; CVCL_1073
Encyclopedic resources Wikidata; Q54751288
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669604
Polymorphism and mutation databases Cosmic; 910687
IARC_TP53; 21177
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number37