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Cellosaurus OSW (CVCL_0B19)

[Text version]
Cell line name OSW
Synonyms Oswald
Accession CVCL_0B19
Resource Identification Initiative To cite this cell line use: OSW (RRID:CVCL_0B19)
Comments Group: Patented cell line.
Part of: FACC canine tumor cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-9116.
Doubling time: 16 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; VGNC; 38196; ASXL1; Simple; p.Gly618fs (c.1850dupG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 40797; FBXW7; Simple; p.Arg694Gln (c.2081G>A); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 42490; KMT2C; Simple; p.Gly976fs (c.2922delG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 42491; KMT2D; Simple; p.Gln5395fs (c.16183delC); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 43761; NF1; Simple; p.Asn58fs (c.167delA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 44567; PTEN; Simple; p.Lys245fs (c.734delA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 112756; SPEN; Simple; p.Ala8fs (c.13_14insG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Arg164His (c.491G>A); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine lymphoma (NCIt: C128121)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Airedale Terrier; VBO=VBO_0200008.
Sex of cell Male
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010235,239
Dog FHC2054151,156
Dog FHC2079279
Dog PEZ1115,123
Dog PEZ12270,288
Dog PEZ20180
Dog PEZ3119,136
Dog PEZ5103
Dog PEZ6176,183
Dog PEZ8240

Run an STR similarity search on this cell line
Publications

PubMed=17532464; DOI=10.1016/j.leukres.2007.04.003
Kisseberth W.C., Nadella M.V.P., Breen M., Thomas R., Duke S.E., Murahari S., Kosarek C.E., Vernau W., Avery A.C., Burkhard M.J., Rosol T.J.
A novel canine lymphoma cell line: a translational and comparative model for lymphoma research.
Leuk. Res. 31:1709-1720(2007)

Patent=US7897150
Kisseberth W.C.
Canine lymphoma cell line and uses thereof.
Patent number US7897150, 01-Mar-2011

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=23365669; DOI=10.1371/journal.pone.0054464; PMCID=PMC3554772
Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D., Modiano J.F., Cvetkovic G., Tepic S.
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
PLoS ONE 8:E54464-E54464(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E.A., Caldwell A., Coy J., Kurihara J.N., Guth A., Regan D.P., Dow S.W.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=29674676; DOI=10.1038/s41598-018-23207-7; PMCID=PMC5908872
Taher L., Beck J., Liu W., Roolf C., Soller J.T., Rutgen B.C., Hammer S.E., Chodisetti M., Sender S., Sterenczak K.A., Fuellen G., Junghanss C., Brenig B., Nolte I., Schutz E., Murua Escobar H.
Comparative high-resolution transcriptome sequencing of lymphoma cell lines and de novo lymphomas reveals cell-line-specific pathway dysregulation.
Sci. Rep. 8:6279-6279(2018)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54936727
Gene expression databases GEO; GSM1974798
Entry history
Entry creation10-Apr-2015
Last entry update10-Sep-2024
Version number14