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Cellosaurus Neuro-2a (CVCL_0470)

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Cell line name Neuro-2a
Synonyms NEURO-2A; Neuro 2a; Neuro2a; Neuro2A; N-2a; N2a; N2A; Nb2a; NB2a
Accession CVCL_0470
Resource Identification Initiative To cite this cell line use: Neuro-2a (RRID:CVCL_0470)
Comments Characteristics: Capable of differentiating into various types of neurons.
Doubling time: ~70 hours (DSMZ=ACC-148).
Karyotypic information: Has a hyper-tetraploid karyotype. Has lost chromosome Y (PubMed=39594637).
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile from personal communication of Rodriguez-Tarduchy Segovia, Gemma.
Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
Cell type: Neural crest derived neuroblast; CL=CL_0002676.
Disease Mouse neuroblastoma (NCIt: C21993)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: A/J.
Hierarchy Parent: CVCL_4343 (C-1300)
Children:
CVCL_B7VJ (Abcam Neuro-2a Arc KO)CVCL_6246 (AGN2a)CVCL_4510 (C1300 CLONE NA)
CVCL_C5RF (N2a #34)CVCL_C5RG (N2a #58)CVCL_E7F3 (N2a APP695-N467K)
CVCL_E7F4 (N2a APP695-N496K)CVCL_E7F5 (N2a APP695-S206A)CVCL_E7F6 (N2a APP695-WT)
CVCL_E7F7 (N2a APP770-N542K)CVCL_E7F8 (N2a APP770-N571K)CVCL_E7F9 (N2a APP770-S206A)
CVCL_E7FA (N2a APP770-WT)CVCL_ZM10 (N2A FLAG-Cdh1)CVCL_A0TK (N2A Psen1/Psen2 dKO)
CVCL_WI11 (N2a-R33)CVCL_WI08 (N2a/Gary)CVCL_D649 (N2aEGFP)
CVCL_D650 (N2aSW)CVCL_RW97 (Na 42/13)CVCL_B436 (NB2a/d1)
CVCL_DF49 (Neuro-2a NucLight Green)CVCL_DF50 (Neuro-2a NucLight Red)CVCL_K046 (Neuro-2a-Luc)
CVCL_C9FD (Neuro-2a/Cas9-Rosa26-Hyg)CVCL_C9FE (Neuro-2a/Cas9-Rosa26-Neo)CVCL_C9FC (Neuro-2a/Cas9-Rosa26-Puro)
CVCL_A9J5 (Neuro-2a/CMV-Luc)CVCL_C9FB (Neuro-2a/HF-Cas9-Rosa26)CVCL_C9FF (Neuro-2a/LoxP-Cas9-hyg-Rosa26)
CVCL_F275 (Neuro-2aTG)CVCL_E6II (Neuro2a (HSE:EGFP))CVCL_D3XR (Neuro2a-RXR)
CVCL_E7G2 (Neuro2A[TRa1])CVCL_E1GT (Neuro2A[TRb1])CVCL_6268 (ScN2a)
CVCL_E0ZD (Ubigene N2A Aldh2 KO)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Direct_author_submission; PubMed=35339896

Markers:
Mouse STR 1-111
Mouse STR 1-217,18
Mouse STR 2-116
Mouse STR 3-212,13,14
Mouse STR 4-221.3,22.3
Mouse STR 5-515,17
Mouse STR 6-418,19 (Direct_author_submission)
18,20 (PubMed=35339896)
Mouse STR 6-712 (Direct_author_submission)
15 (PubMed=35339896)
Mouse STR 7-125.2
Mouse STR 8-116,17
Mouse STR 11-215
Mouse STR 12-116
Mouse STR 13-116.2,17.2
Mouse STR 15-321.3,22.3,23.3
Mouse STR 17-216
Mouse STR 18-322 (Direct_author_submission)
22,23 (PubMed=35339896)
Mouse STR 19-212
Mouse STR X-126,27

Run an STR similarity search on this cell line
Web pages Info; ResearchGate; -; https://www.researchgate.net/post/What_are_the_details_of_N2A_cell_differentiation_methods
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-213.html
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-384.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/N2a_cell
Publications

PubMed=11470893; DOI=10.1073/pnas.151242598; PMCID=PMC55414
Masatoshi Enari, Eckhard Flechsig, Charles Weissmann;
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.
Proc. Natl. Acad. Sci. U.S.A. 98:9295-9299(2001)

PubMed=14504404; DOI=10.1073/pnas.1834432100; PMCID=PMC208815
Peter-Christian Klohn, Lars Stoltze, Eckhard Flechsig, Masatoshi Enari, Charles Weissmann;
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
Proc. Natl. Acad. Sci. U.S.A. 100:11666-11671(2003)

DOI=10.5352/JLS.2009.19.4.449
Jin Hwan Do, In Su Kim, Hyun Myung Ko, Dong-Kug Choi;
High resolution genomic profile of Neuro2a murine neuroblastoma cell line by array-based comparative genomic hybridization.
J. Life Sci. 19:449-456(2009)

PubMed=19903493; DOI=10.1016/j.jneumeth.2009.11.004
Roger G. Tremblay, Marianna Sikorska, Jagdeep K. Sandhu, Patricia Lanthier, Maria Ribecco-Lutkiewicz, Mahmud Bani-Yaghoub;
Differentiation of mouse Neuro 2A cells into dopamine neurons.
J. Neurosci. Methods 186:60-67(2010)

PubMed=25193168; DOI=10.1074/mcp.M113.037291; PMCID=PMC4256493
Daniel Hornburg, Carsten Drepper, Falk Butter, Felix Meissner, Michael Sendtner, Matthias Mann;
Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.
Mol. Cell. Proteomics 13:3410-3420(2014)

PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738
John Paul Didion, Ryan J. Buus, Zohreh Naghashfar, David W. Threadgill, Herbert Carpenter Morse 3rd, Fernando Pardo-Manuel de Villena;
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.
BMC Genomics 15:847.1-847.11(2014)

PubMed=25565633; DOI=10.1371/journal.pone.0117154; PMCID=PMC4286239
Anja Maria Oelschlegel, Markus Geissen, Matthias Lenk, Roland Riebe, Marlies Angermann, Hermann Schaetzl, Martin H. Groschup;
A bovine cell line that can be infected by natural sheep scrapie prions.
PLoS ONE 10:e0117154.1-e0117154.15(2015)

PubMed=35339896; DOI=10.1016/j.ebiom.2022.103970; PMCID=PMC8956943
Qiu-Zhi Zhou, Shi-Hong Li, Meng-Zhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, En-Jie Liu, Jian-Zhi Wang;
Human tau accumulation promotes glycogen synthase kinase-3beta acetylation and thus upregulates the kinase: a vicious cycle in Alzheimer neurodegeneration.
EBioMedicine 78:103970.1-103970.18(2022)

PubMed=39594637; DOI=10.3390/cells13221889; PMCID=PMC11593031
Lioba Hergenhahn, Niklas Padutsch, Shaymaa Azawi, Ralf Weiskirchen, Thomas Liehr, Martina Rincic;
Cytogenomic characterization of murine neuroblastoma cell line Neuro-2a and its two derivatives Neuro-2a TR-alpha and Neuro-2a TR-beta.
Cells 13:1889.1-1889.11(2024)

Cross-references
Cell line collections (Providers) Abcam; ab279975
ATCC; CCL-131
BCRC; 60026
BCRJ; 0189
CCLV; CCLV-RIE 0132
CCTCC; GDC0162
CLS; 400394
DSMZ; ACC-148
ECACC; 89121404
ICLC; ATL99007
IZSLER; BS TCL 128
JCRB; IFO50081
KCB; KCB 2014025YJ
RCB; RCB2639
TKG; TKG 0509
Cell line databases/resources CLO; CLO_0008154
CLO; CLO_0050180
MCCL; MCC:0000368
CLDB; cl3682
CLDB; cl3683
CLDB; cl3684
CLDB; cl3685
CLDB; cl4956
CLDB; cl5236
CCRID; 1101MOU-PUMC000291
CCRID; 3101MOUSCSP5035
CCRID; 3101MOUTCM29
CCRID; 4201MOU-CCTCC00162
DSMZCellDive; ACC-148
Lonza; 451
TOKU-E; 2746
TOKU-E; 3552
TOKU-E; 3563
Anatomy/cell type resources BTO; BTO_0001976
CRISP screens repositories BioGRID_ORCS_Cell_line; 1373
Chemistry resources ChEMBL-Cells; CHEMBL3307521
ChEMBL-Targets; CHEMBL614062
PubChem_Cell_line; CVCL_0470
Encyclopedic resources Wikidata; Q18391478
Experimental variables resources EFO; EFO_0022756
Proteomic databases PRIDE; PXD000065
PRIDE; PXD000666
PRIDE; PXD002290
PRIDE; PXD018875
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number36