• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792; ATCC=CRL-1427).
  
• Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
  

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PubMed=7873286; DOI=10.1016/8756-3282(94)90305-0
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PubMed=9600771; DOI=10.1016/S8756-3282(98)00007-6
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PubMed=15736406
Christoph Pautke, Matthias Schieker, Thomas Tischer, Andreas Kolk, Peter Neth, Wolf Mutschler, Stefan Milz;
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PubMed=19160414; DOI=10.1002/jcp.21667
Riccardo Di Fiore, Andrea Santulli, Rosa Drago-Ferrante, Michela Giuliano, Anna De Blasio, Concetta Messina, Giuseppe Pirozzi, Virginia Tirino, Giovanni Tesoriere, Renza Vento;
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PubMed=19363654; DOI=10.1007/s10585-009-9259-6
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Establishment and characterization of a new highly metastatic human osteosarcoma cell line.
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PubMed=19787792; DOI=10.1002/gcc.20717
Laura Ottaviano, Karl-Ludwig Schaefer, Melanie Gajewski, Wolfgang Huckenbeck, Stefan E. Baldus, Uwe Rogel, Carlos Mackintosh, Enrique de Alava, Ola Myklebost, Stine Henrichson Kresse, Leonardo Andres Meza-Zepeda ...Show all 18 authors... , Massimo Serra, Anne-Marie Cleton-Jansen, Pancras Cornelis Wilhelmus Hogendoorn, Horst Buerger, Thomas Aigner, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
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PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
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PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
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A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Alexander B. Mohseny, Isidro Machado, Yong-Ping Cai, Karl-Ludwig Schaefer, Massimo Serra, Pancras Cornelis Wilhelmus Hogendoorn, Antonio Llombart-Bosch, Anne-Marie Cleton-Jansen;
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
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PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23144859; DOI=10.1371/journal.pone.0048262; PMCID=PMC3492335
Stine Henrichson Kresse, Halfdan Rydbeck, Magne Skarn, Heidi Maria Namlos, Ana Heslanyeth Barragan-Polania, Anne-Marie Cleton-Jansen, Massimo Serra, Knut Liestol, Pancras Cornelis Wilhelmus Hogendoorn, Eivind Hovig, Ola Myklebost, Leonardo Andres Meza-Zepeda;
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:e48262.1-e48262.20(2012)

PubMed=23129384; DOI=10.1002/jcp.24272
Riccardo Di Fiore, Daniele Fanale, Rosa Drago-Ferrante, Ferdinando Chiaradonna, Michela Giuliano, Anna De Blasio, Valeria Amodeo, Lidia Rita Corsini, Viviana Bazan, Giovanni Tesoriere, Renza Vento, Antonio Russo;
Genetic and molecular characterization of the human osteosarcoma 3AB-OS cancer stem cell line: a possible model for studying osteosarcoma origin and stemness.
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PubMed=24903274; DOI=10.1096/fj.14-249714; PMCID=PMC5395736
Alain Guignandon, Celine Faure, Thibaut Neutelings, Aline Rattner, Pierre Mineur, Marie-Therese Linossier, Norbert Laroche, Charles A. Lambert, Christophe Deroanne, Betty V. Nusgens, Rene Demets ...Show all 13 authors... , Alain Colige, Laurence Vico; Show fewer authors
Rac1 GTPase silencing counteracts microgravity-induced effects on osteoblastic cells.
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PubMed=25382592; DOI=10.1021/pr500907d
Ines Lamego, Iola F. Duarte, M. Paula M. Marques, Ana M. Gil;
Metabolic markers of MG-63 osteosarcoma cell line response to doxorubicin and methotrexate treatment: comparison to cisplatin.
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PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
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PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26320182; DOI=10.18632/oncotarget.5177; PMCID=PMC4745740
Ling Ren, Arnulfo Mendoza, Jack Zhu, Joseph W. Briggs, Charles Halsey, Ellen S. Hong, Sandra Sczerba Burkett, James J. Morrow, Michael M. Lizardo, Tanasa Osborne, Samuel Q. Li ...Show all 14 authors... , Hue H. Luu, Paul S. Meltzer, Chand Khanna; Show fewer authors
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
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PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
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A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
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PubMed=29334376; DOI=10.1038/nm.4475; PMCID=PMC5803371
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Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
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PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
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PubMed=36480329; DOI=10.1002/adbi.202200194
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Establishment and characterization of single and triple-agent resistant osteosarcoma cell lines.
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