Cellosaurus logo
expasy logo

Cellosaurus LAMA-84 (CVCL_0388)

[Text version]
Cell line name LAMA-84
Synonyms Lama-84; LAMA84; Lama84
Accession CVCL_0388
Resource Identification Initiative To cite this cell line use: LAMA-84 (RRID:CVCL_0388)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Doubling time: 48 hours (PubMed=3476310); 36 hours (PubMed=25984343); ~50 hours (DSMZ=ACC-168).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827; PubMed=20809971; DepMap=ACH-000301).
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (Cosmic-CLP=907783; DepMap=ACH-000301).
HLA typing Source: DSMZCellDive=ACC-168
Class I
HLA-AA*02:01:01,25:01:01
HLA-BB*18:01:01,44:02:01
HLA-CC*05:01:01,12:03:01
Class II
HLA-DPDPA1*01:03:01,02:01:01
HLA-DQDQB1*06:02:01,06:02:01
HLA-DRDRA*01:01:01,01:02:03
DRB1*15:01:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African14.08
Native American0
East Asian, North1.13
East Asian, South1.46
South Asian1.64
European, North29.64
European, South52.05
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1826 (LAMA-87)CVCL_9540 (LAMA-88)CVCL_DP57 (LAMA84-r)
CVCL_DP54 (LAMA84-rn)CVCL_UE08 (LAMA84-s)CVCL_AE17 (LAMA84R)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000685; CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168; Millipore=SCC140

Markers:
AmelogeninX
CSF1PO8,11,12 (DSMZ=ACC-168)
11,12 (CCRID=1101HUM-PUMC000685; Cosmic-CLP=907783; Millipore=SCC140)
11,12,13 (CLS=300261)
D1S165615,15.3
D2S133817 (CLS=300261; DSMZ=ACC-168)
17,19 (CCRID=1101HUM-PUMC000685)
D3S135814,17
D5S81811,12
D6S104310,20
D7S82011
D8S117910,15
D12S39118,24
D13S31711 (CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168; Millipore=SCC140)
11,12 (CCRID=1101HUM-PUMC000685)
D16S53911
D18S5113
D19S43313
D21S1129,30,31 (CLS=300261; DSMZ=ACC-168)
29,31 (CCRID=1101HUM-PUMC000685; Millipore=SCC140)
FGA21,22
Penta D10
Penta E7
TH016,7
TPOX10 (CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168)
10,11 (CCRID=1101HUM-PUMC000685; Millipore=SCC140)
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=3476310
Seigneurin D., Champelovier P., Mouchiroud G., Berthier R., Leroux D., Prenant M., McGregor J., Starck J., Morle F., Micouin C., Pietrantuono A., Kolodie L.
Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics.
Exp. Hematol. 15:822-832(1987)

PubMed=7996872; DOI=10.1016/0145-2126(94)90102-3
Champelovier P., Valiron O., Jacrot M., Leroux D., Seigneurin D.
Selection and characterization of an erythroeosinophilic subclone (LAMA-87) and an eosinophilic subclone (LAMA-88) from the multipotential cell line LAMA-84.
Leuk. Res. 18:903-918(1994)

PubMed=8693292; DOI=10.1046/j.1365-3083.1996.d01-84.x
Blom T., Nilsson G., Sundstrom C., Nilsson K., Hellman L.
Characterization of a human basophil-like cell line (LAMA-84).
Scand. J. Immunol. 44:54-61(1996)

PubMed=9257809
Champelovier P., Fixe P., Valiron O., Feige J.-J., Praloran V., Seigneurin D.
Proliferation of LAMA-84 and LAMA-87 cell lines is modulated by autocrine loops involving M-CSF and TGF-beta.
Exp. Hematol. 25:958-965(1997)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125
Virgili A., Nacheva E.
Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.
Mol. Cytogenet. 3:15.1-15.12(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300261
DSMZ; ACC-168
Millipore; SCC140
Cell line databases/resources CLO; CLO_0007238
MCCL; MCC:0000283
CLDB; cl3168
cancercelllines; CVCL_0388
CCRID; 1101HUM-PUMC000685
Cell_Model_Passport; SIDM00346
Cosmic-CLP; 907783
DepMap; ACH-000301
DSMZCellDive; ACC-168
LINCS_LDP; LCL-1109
Lonza; 961
Anatomy/cell type resources BTO; BTO:0004465
Biological sample resources BioSample; SAMN03473363
BioSample; SAMN10988484
Chemistry resources ChEMBL-Cells; CHEMBL3308267
ChEMBL-Targets; CHEMBL2366090
GDSC; 907783
PharmacoDB; LAMA84_818_2019
PubChem_Cell_line; CVCL_0388
Encyclopedic resources Wikidata; Q54901914
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM887262
GEO; GSM888337
GEO; GSM1670031
Polymorphism and mutation databases Cosmic; 787500
Cosmic; 907783
Cosmic; 1012081
Cosmic; 1019834
Cosmic; 1026569
Cosmic; 1078729
IARC_TP53; 21457
LiGeA; CCLE_403
Progenetix; CVCL_0388
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number42