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Cellosaurus HDLM-2 (CVCL_0009)

[Text version]
Cell line name HDLM-2
Synonyms HD-LM-2; HDLM2
Accession CVCL_0009
Resource Identification Initiative To cite this cell line use: HDLM-2 (RRID:CVCL_0009)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~70-75 hours (DSMZ=ACC-17).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Cell surface proteome.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; 11896; TNFAIP3; Simple; p.Met174fs (c.520_548dup) (dup 586-614); Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; 11998; TP53; Unexplicit; Fusion with an Alu-element at the Ex7-Ex8 junction; Zygosity=Unspecified (PubMed=17065008).
HLA typing Source: DSMZCellDive=ACC-17
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*08:01:01,44:02:01
HLA-CC*05:01:01,07:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*03:01:01,04:01:01
HLA-DQDQA1*01:02:01,01:03:01
DQB1*06:02:01,06:03:01
HLA-DRDRA*01:02:02,01:02:03
DRB1*13:01:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.09
Native American0
East Asian, North1.64
East Asian, South0
South Asian0.05
European, North62.14
European, South35.08
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_M696 (HDLM-2d)
Originate from same individual CVCL_M693 ! HDLM-1
CVCL_M697 ! HDLM-3
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=924110; DSMZ=ACC-17

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817
D3S135814,15
D5S81811
D7S8208,10
D8S117913,14
D13S31711,12
D16S53912
D18S5114
D19S43312,15
D21S1129
FGA21,23
Penta D13,14
Penta E12
TH016,7
TPOX8
vWA19

Run an STR similarity search on this cell line
Web pages https://www.proteinatlas.org/learn/cellines
Publications

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Drexler H.G., Gaedicke G., Lok M.-S., Diehl V., Minowada J.
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2602652; DOI=10.1007/978-3-642-83781-4_8
Drexler H.G., Gignac S.M., Hoffbrand A.V., Leber B.F., Norton J.D., Lok M.-S., Minowada J.
Characterization of Hodgkin's disease derived cell line HDLM-2.
Recent Results Cancer Res. 117:75-82(1989)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=17065008; DOI=10.1080/10428190600667721
Feuerborn A., Moritz C., von Bonin F., Dobbelstein M., Trumper L., Sturzenhofecker B., Kube D.
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030
Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S., Stanelle J., Siebert R., Kuppers R.
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-17
Cell line databases/resources CLO; CLO_0003671
CLDB; cl1580
cancercelllines; CVCL_0009
Cell_Model_Passport; SIDM01064
Cosmic-CLP; 924110
DepMap; ACH-000267
DSMZCellDive; ACC-17
IGRhCellID; HDLM2
LINCS_LDP; LCL-2007
Biological sample resources BioSample; SAMN03473364
BioSample; SAMN10988513
Chemistry resources ChEMBL-Cells; CHEMBL3308234
ChEMBL-Targets; CHEMBL2366231
GDSC; 924110
PharmacoDB; HDLM2_521_2019
PubChem_Cell_line; CVCL_0009
Encyclopedic resources Wikidata; Q54882175
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM335390
GEO; GSM381298
GEO; GSM499724
GEO; GSM499732
GEO; GSM552430
GEO; GSM646534
GEO; GSM887064
GEO; GSM888134
GEO; GSM1669870
Polymorphism and mutation databases Cosmic; 924110
Cosmic; 988701
Cosmic; 1013909
Cosmic; 1086355
Cosmic; 1278832
Cosmic; 1289699
Cosmic; 1290220
Cosmic; 1432040
Cosmic; 2276322
Cosmic; 2464309
IARC_TP53; 23613
Progenetix; CVCL_0009
Proteomic databases PRIDE; PXD000589
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number41