Cellosaurus NB4 (CVCL_0005)
Cell line name | NB4 | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synonyms | NB-4; NB.4 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0005 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: NB4 (RRID:CVCL_0005) | ||||||||||||||||||||||||||||||||||||
Comments | Group: Patented cell line. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 3. Part of: LL-100 blood cancer cell line panel. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030. Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045. Population: Caucasian. Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ=ACC-207). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: CTCF ChIP-seq epigenome analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: DNA methylation analysis. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. | ||||||||||||||||||||||||||||||||||||
Sequence variations |
| ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=26589293
Source: CLS=300299
Source: DSMZCellDive=ACC-207
| ||||||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
| ||||||||||||||||||||||||||||||||||||
Disease | Acute promyelocytic leukemia with PML-RARA (NCIt: C3182) Acute promyelocytic leukemia (ORDO: Orphanet_520) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
| ||||||||||||||||||||||||||||||||||||
Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 23Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): CLS=300299; Cosmic-CLP=1323913; DSMZ=ACC-207; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://www.proteinatlas.org/learn/cellines http://genome.ucsc.edu/ENCODE/protocols/cell/human/NB4_protocol.pdf | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=1995093; DOI=10.1182/blood.V77.5.1080.1080 PubMed=1453773 PubMed=7630193 Patent=US5589345 PubMed=9737686; DOI=10.1038/sj.leu.2401112 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=11704857; DOI=10.1038/sj.onc.1204863 PubMed=12353268; DOI=10.1002/gcc.10117 PubMed=14504097; DOI=10.1182/blood-2003-02-0418 PubMed=15843827; DOI=10.1038/sj.leu.2403749 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027 PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544 PubMed=23955599; DOI=10.1038/ng.2731 PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652 PubMed=25877200; DOI=10.1038/nature14397 PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469 PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786 PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103 PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646 PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | CLS; 300299
DSMZ; ACC-207 NCBI_Iran; C515 Ubigene; YC-C122 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0007947
MCCL; MCC:0000350 CLDB; cl3643 cancercelllines; CVCL_0005 Cell_Model_Passport; SIDM00428 Cosmic-CLP; 1323913 DepMap; ACH-000294 DSMZCellDive; ACC-207 LINCS_LDP; LCL-1084 Lonza; 749 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0002136 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03470835
BioSample; SAMN10988571 ENCODE; ENCBS032SIL ENCODE; ENCBS259AAA ENCODE; ENCBS390ENC | ||||||||||||||||||||||||||||||||||||
CRISP screens repositories | BioGRID_ORCS_Cell_line; 212 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308423
ChEMBL-Targets; CHEMBL614188 GDSC; 1323913 PharmacoDB; NB4_990_2019 PubChem_Cell_line; CVCL_0005 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54907527 | ||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0002798 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSM236798 GEO; GSM236834 GEO; GSM472929 GEO; GSM510512 GEO; GSM510513 GEO; GSM887349 GEO; GSM888426 GEO; GSM945252 GEO; GSM945275 GEO; GSM749716 GEO; GSM1022643 GEO; GSM1374696 GEO; GSM1374697 GEO; GSM1446740 GEO; GSM1670151 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 787463
Cosmic; 850391 Cosmic; 922661 Cosmic; 924050 Cosmic; 975285 Cosmic; 981582 Cosmic; 996313 Cosmic; 1012107 Cosmic; 1037664 Cosmic; 1070692 Cosmic; 1078721 Cosmic; 1089522 Cosmic; 1127257 Cosmic; 1181601 Cosmic; 1523826 Cosmic; 1524838 Cosmic; 1601063 Cosmic; 1604862 Cosmic; 1779130 Cosmic; 2036677 Cosmic; 2089653 Cosmic; 2131548 Cosmic; 2306227 Cosmic; 2579202 IARC_TP53; 21530 IARC_TP53; 21705 LiGeA; CCLE_910 Progenetix; CVCL_0005 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000589
PRIDE; PXD001610 PRIDE; PXD030304 | ||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000978 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||||||
Version number | 44 |